2016 Fiscal Year Final Research Report
Structural basis for innate immune pathogen sensors
| Project/Area Number |
26711002
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Structural biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ohto Umeharu 東京大学, 薬学研究科(研究院), 准教授 (90451856)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 構造生物学 / 結晶構造解析 |
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| Outline of Final Research Achievements |
We conducted structural studies on the innate immune receptors, TLR7, TLR8, TLR9, and NOD2. We determined the crystal structures of TLR7 and TLR8 in complex with ssRNA, and also determined the crystal structure of TLR9 in complex with CpG DNA, which revealed the activation mechanism of these nucleic acid recognizing TLRs. Moreover, we determined the crystal structure of an ADP-bound inactivated form of NOD2.
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| Free Research Field |
構造生物学
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