2015 Fiscal Year Final Research Report
Molecular mechanisms of piRNA biogenesis
| Project/Area Number |
26711006
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
Saito Kuniaki 慶應義塾大学, 医学部, 准教授 (30423396)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 発現制御 / 遺伝子 / RNA / プロセシング / 輸送 |
|---|
| Outline of Final Research Achievements |
In Drosophila ovarian somatic cells (OSCs), we discovered a cytoplasmic granular body named as flam body, where piRNA precursors accumulate (Murota et al. Cell Reports 2014). flam body is closely localized and partially overlapped with Yb body. Disruption of Yb expression in OSCs abolished flam body signals, suggesting that flam body and Yb body are interacted with each other in the process of piRNA biogenesis.
|
| Free Research Field |
分子生物学
|
