2016 Fiscal Year Final Research Report
Probing the epigenetic mechano-chemical regulatory mechanism in the cell lineage by micromechanical manipulation of the early embryo
| Project/Area Number |
26711009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Waseda University |
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Principal Investigator |
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| Research Collaborator |
ISHIWATA Shin'ichi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 細胞分裂 |
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| Outline of Final Research Achievements |
During cellular development and growth, the mechanical force generated inside and outside a mitotic cell plays a critical role in cellular functions such as changes in cell morphology and the determination of cell division axis. We planned to develop techniques to probe how the cell lineage is affected by the externally applied force to the early embryo. The main results of this project are summarized as follows: (1) Using micromanipulation technique, we found that mechanical properties of spindle poles are symmetrically balanced. (2) The rigidity of surrounding environment affects the process of cell division. (3)We developed the technique to probe the epigenetic mechano-chemical regulatory mechanism in the cell lineage by micromechanical manipulation of the early embryo.
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| Free Research Field |
生物物理学
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