2017 Fiscal Year Final Research Report
Microtubule generation independent of centrosomes
| Project/Area Number |
26711012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
Goshima Gohta 名古屋大学, 理学研究科, 教授 (20447840)
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| Research Collaborator |
WATANABE Sadanori
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 微小管 / オーグミン |
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| Outline of Final Research Achievements |
This research project aimed to understand the mechanism of centrosome-independent microtubule generation. The major outcomes are as follows: (1) The augmin complex has been shown required for centrosome-independent microtubule nucleation within the mitotic spindle in animal and plant cells. Here, we identified augmin in the filamentous fungus, elucidating the evolutionary conservation of this protein complex. (2) We generated knockout mice of a critical augmin subunit, and identified a defect in MTOC clustering during early embryonic division. (3) Microtubule nucleation independent of centrosomes or augmin was identified in the moss Physcomitrella patens.
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| Free Research Field |
細胞生物学
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