Determination of regeneration inducers in urodele amphibians

2017 Fiscal Year Final Research Report

• Project/Area Number: 26711015
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Okayama University
• Principal Investigator: satoh akira 岡山大学, 異分野融合先端研究コア, 准教授 (90512004)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 四肢再生

Outline of Final Research Achievements

This study aims for identification of nerve molecules, which regulate blastema induction phase in amphibian limb regeneration. It has been well described that nerve plays an essential roles in blastema induction. However, identification of nerve factors had not been achieved over 190 years. We approached this issue with a brand-new experimental model called the accessory limb model, which we established recently. What we found in this study was that Fibroblast growth factors (Fgfs) and Bone morphogenic protein (Bmp) could substitute for nerve roles in blastema induction. Moreover, we demonstrated that our defined molecules can induce organ-level regeneration in multiple organs and species.

Free Research Field

再生生物学