2017 Fiscal Year Final Research Report
Innovation of novel technology in meat quality regulation by agricultural by-products with PPARdelta agonistic activities
| Project/Area Number |
26712023
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 骨格筋 / 筋線維タイプ / 肉質 / PPARδ / 遅筋 / 速筋 / 食肉生産 / ブタ |
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| Outline of Final Research Achievements |
Muscles having abundant slow fiber type exhibit good meat quality and tenderness. Activation of peroxisome proliferator-activated receptor (PPAR)delta is thought to induce fast-to-slow fiber type transition. Here, we measured and searched various PPARdelta agonistic activities from various agricultural products and by-products. We found the extracts of both Yukireitake mushroom and the mushroom bed showed potent PPARdelta agonistic activities. The expression level of PPARdelta target genes after the administration of these extracts tended to be up-regulated dose-dependently via interperitoneal injection. Meanwhile, these activities were diminished when orally injected. Thus, to obtain the PPARdelta agonistic activities of Yukireitake mushroom or mushroom bed, it is needed to find a way to avoid the effects of a digestive tract.
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| Free Research Field |
筋細胞生物学・食肉科学
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