2016 Fiscal Year Final Research Report
Sensing, processing and neurotransmission of taste in the taste buds
| Project/Area Number |
26713008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TARUNO Akiyuki 京都府立医科大学, 医学(系)研究科(研究院), 講師 (20706824)
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| Research Collaborator |
Sun Hongxin
Kashio Makiko
Marunaka Yoshinori
Miyazaki Hiroaki
Niisato Naomi
Nakajo Koichi
Kido Mizuho
Murakami Tatsuro
Nambu Atsushi
Kobayashi Kenta
Sano Hiromi
Matsumoto Ichiro
Foskett J. Kevin
Tordoff Michael G.
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 味覚 / イオンチャネル / 神経伝達 / ATP / CALHM |
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| Outline of Final Research Achievements |
The sense of taste controls our eating behaviors. Full understanding of the taste mechanisms is invaluable for preventing lifestyle diseases such as diabetes and hypertension. We previously reported that CALHM1, a subunit of a voltage-gated plasma membrane ion channel, is an essential portion of the neurotransmitter release channel in taste bud cells. However, rigorous regulation of CALHM1 channel function by unknown mechanisms has been implicated in vivo. In this study, we discovered two regulatory mechanisms of CALHM1 channel: (1) CALHM1 gating and submembrane distribution is post-translationally regulated by S-palmitoylation, and (2) a CALHM1 paralog, CALHM3, forms a novel oligomeric ion channel with CALHM1 and the CALHM1/3 channel mediates neurotransmission of sweet, bitter, umami and amiloride-insensitive salt tastes.
These findings significantly advance our molecular understanding of taste mechanisms.
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| Free Research Field |
生理学
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