Megakaryocytes determine the cell fate of hematopoietic stem cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 26713035
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Hematology
• Research Institution: Kumamoto University
• Principal Investigator: Nakamura-Ishizu Ayako 熊本大学, 国際先端医学研究機構, 客員准教授 (10548548)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 造血幹細胞 / 巨核球 / 分化 / ニッチ

Outline of Final Research Achievements

The maintenance, proliferation and differentiation of hematopoietic stem cell (HSC) within the bone marrow (BM) microenvironment is essential for healthy hematopoiesis. in this project we have investigated the role of mature megakaryocytes in regulating hematopoietic stem cells in the BM. Wh have characterized CLEC2 expressing Megakaryocvtes as potent niche cells and have reported their function in maintaining HSCs in quiescence. We are further preparing to report the effect of CLEC2 receptor podoplanin in BM hematopoiesis and the role of the cytokine, Thrombopoietin in determining HSC cell fate.

Free Research Field

実験血液学