2017 Fiscal Year Final Research Report
Translational research of psychiatric disorders focusing on neuron-glia interaction using regenerative medicine techniques
| Project/Area Number |
26713039
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | ミクログリア / 精神疾患 / 直接誘導ミクログリア様細胞 / 直接誘導ニューロン / 統合失調症 / うつ病 / 炎症仮説 |
|---|
| Outline of Final Research Achievements |
We have originally developed a novel technique to induce microglia-like (iMG) cells directly from human peripheral blood (monocytes) by applying only two cytokines IL-34 and GM-CSF within two weeks without any gene modifications. Compared to the iPS cells, our iMG technique is simpler and has advantages of time and cost management. We have revealed abnormalities in cellular responses of iMG cells derived from patients with (1) Nasu-Hakola disease which is a known primary microglia disease. (2) bipolar disorder, and (3) fibromyalgia.
Direct conversion technique to produce induced-neuronal (iN) cells from human fibroblasts within 2 weeks is expected to discover unknown neuronal phenotypes of neuropsychiatric disorders. We have developed early-stage iN cells within a week. We have revealed unique gene expression profiles in iN cells and early-stage iN cells from patients with neurofibromatosis type 1 (NF1).
|
| Free Research Field |
精神神経科学
|
