Approaches to control in vivo dynamics of nanoparticle carriers for diagnosis and therapy in nuclear medicinal fields

2016 Fiscal Year Final Research Report

• Project/Area Number: 26713040
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: MAKINO Akira 福井大学, 高エネルギー医学研究センター, 准教授 (00566226)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ナノ粒子 / 核医学イメージング / 内照射治療

Outline of Final Research Achievements

For the development of the image-based therapy using nanoparticle carriers, shortening the waiting time from the probe dosage to the imaging, and reduction of non-specific radiation exposures caused by RI labeled nanoparticle circulating blood is important issues.
In this study, we investigated a method to forcibly remove nanoparticles circulating in blood. Using anti-nanoparticle antibody, we succeeded in greatly reducing the nanoparticle in blood, which causes for the undesired background signal on imaging. Additionally, we also developed nanoparticle type drug for internal radiation therapy using Auger electron emission nuclide with short radiation range, which is expected to be able to suppress nonspecific exposure.

Free Research Field

分子イメージング