2016 Fiscal Year Final Research Report
Homeostatic interaction between locomotor and immune system induced with mechanical stress
| Project/Area Number |
26713052
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Hayashi Mikihito 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (50581914)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メカニカルストレス / 骨細胞 / 運動器 |
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| Outline of Final Research Achievements |
Tissues and cells are coordinated and remodeled to adapt to various environmental situations by sensing and transducing the signals induced by mechanical stress. It is well known that the human body homeostasis cannot maintain in the condition of microgravity. In this study, from the transcriptomic screening and functional analysis, we identified the immunoregulatory factors expressed in locomotor system induced by mechanical loading/unloading and analyzed conditional knockout mice in which these factors are deleted in skeletal muscle and/or osteocytes.
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| Free Research Field |
骨代謝学
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