Regulation of postprandial vascular inflammation by food components: potential roles of miRNA-mRNA networks

2016 Fiscal Year Final Research Report

• Project/Area Number: 26750038
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Ochanomizu University
• Principal Investigator: KISHIMOTO Yoshimi お茶の水女子大学, お茶大アカデミック・プロダクション, 寄附研究部門准教授 (70600477)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 動脈硬化 / 血管炎症 / miRNA

Outline of Final Research Achievements

This study was conducted to address if postprandial vascular inflammation is regulated by miRNA-mRNA networks and to evaluate the effects of various food components on the regulatory system. In the cultured cell-based assay, we found that the endothelial inflammation and the cell death were evoked after palmitic acid or glucose exposure, while some functional food factors (e.g. polyphenols) could attenuate the inflammatory responses. The up-regulations of mRNA expression of inflammation-related genes were observed in the isolated peripheral blood mononuclear cells after intake of the fatty meal in the human study. miRNA-mRNA networks might have a impact on the regulation of postprandial vascular inflammation.

Free Research Field

食生活学、食品機能学、分子栄養学