The risk factor of malnutrition in head and neck cancer patients undergoing chemoradiotherapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 26750042
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: YASUI Sonoko 徳島大学, 大学院医歯薬学研究部, 助教 (30716634)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 頭頸部癌 / 化学放射線療法 / 低栄養 / 栄養評価 / BIA

Outline of Final Research Achievements

(1) We measured the time-course change of body composition by bioelectrical impedance analysis. We compared the body composition before treatment and 8 weeks after treatment. Although the body weight and skeletal muscle mass decreased significantly, there was no significant difference in body fat mass. (2) We classified the patients into two groups by high and low creatinine height index (CHI). In low CHI group, there was higher ratio of severe hematological toxicity, more delayed days of radiotherapy, and less survival rate. In this study, although we could not elucidate the factor of muscle mass reduction, our results suggested the low muscle mass at pre-treatment was likely to associate to severe hematological toxicity and the interruption of treatment.

Free Research Field

臨床栄養