Energy balance of the low protein diet on diabetic nephropathy

2015 Fiscal Year Final Research Report

• Project/Area Number: 26750047
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: Yoshida Takuya 静岡県立大学, 食品栄養科学部, 助教 (80622448)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 糖尿病性腎症 / 高脂肪食 / 低たんぱく食 / 脂肪蓄積

Outline of Final Research Achievements

To compare the effects of a low carbohydrate and high fat diet with a traditional high carbohydrate and low fat diet on markers of blood glucose and renal function in the rats of diabetic nephropathy. In this study, high fat diet reduced renal function and injured renal tissue more than high carbohydrate diet, even under energy restriction conditions. The high fat diet induced the ectopic fat depots in the proximal tubular cells in the diabetic nephropathy model rats. These findings suggest that high fat diet not recommended in diabetic nephropathy.

Free Research Field

臨床栄養学