Intrauterine hyperglycemia-induced inflammatory signalling via the receptor for advanced glycation end products in the cardiac muscle of the infants of diabetic mother rats.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26750054
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Takasaki University of Health and Welfare
• Principal Investigator: RITSUKO KAWAHARADA (那須律子) 高崎健康福祉大学, 健康福祉学部, 講師 (60383147)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 妊娠 / エイコサペンタエン酸

Outline of Final Research Achievements

Gestational diabetes is associated with increased risk to the health of the mother and her offspring. We have previously reported that IDMs showed abnormalities in cardiac Akt-related insulin signalling, and that these deficiencies in Akt-related signalling were attenuated by supplementing the maternal diet with fish-oil.Pregnant diabetic rats were administered streptozotocin before receiving EPA. Insulin resistance as determined by diminished GLUT4 translocation following insulin stimulation, the levels of AGEs and ROS were elevated in the neonatal hearts of IDM/W compared with that seen in the offspring born from non-diabetic control animals. Similarly, the RAGEs mRNA levels, ROS and the amount of NF-κB　mRNA were higher in the hearts from the IDM/W when compared to that observed in the hearts of offspring born to non-diabetic animals. These deleterious effects of gestational diabetes were significantly decreased in the offspring of diabetic mothers receiving EPA supplementation.

Free Research Field

糖尿病