Identification of the promoter proteins for pancreatic cancer which concurred with diabetes and research of effect of the compounds in citrus fruits which investigation is approached from AGEs.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26750056
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kanazawa Medical University
• Principal Investigator: TAKATA Takanobu 金沢医科大学, 総合医学研究所, 助教 (20515308)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 膵癌 / 食習慣 / 糖尿病 / 生活習慣病 / TAGE

Outline of Final Research Achievements

Pancreatic cancer is related to diabetes. However, their causal relationship remains unclear. Toxic advanced glycation end products (toxic AGEs, named TAGE), involved in diabetic vascular complications (e.g., lifestyle-related diseases), are related to cancer. Based on this finding, we hypothesized that TAGE promote the development and progression of pancreatic cancer.
In an experiment with a fructose/glucose metabolic intermediate, glyceraldehyde (GA), i.e., the causative agent of TAGE, added to the culture medium for PANC-1 cells derived from pancreatic cancer (pancreatic duct cancer model), the production and accumulation of intracellular TAGE increased along with an increased concentration of GA incorporated into the cells. In addition, abnormalities were found in proteins involved in cancer invasion and cell death.

Free Research Field

糖尿病