2016 Fiscal Year Final Research Report
Identification of compement factor trigger production of C3a and C5a during hemodialysis
| Project/Area Number |
26750151
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
OHSAWA Isao 順天堂大学, 医学部, 准教授 (60407252)
TOMINO Yasuhiko 順天堂大学, 医学部, 教授 (60130077)
HONDA Daisuke 順天堂大学, 腎臓内科学講座, 大学院生 (50790094)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 補体活性化 / 生体適合性 / 透析膜 / 血液透析 / C3a・C5a |
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| Outline of Final Research Achievements |
Hemodialysis is a process of purifying the blood of a person whose kidneys are not working normally. During the hemodialysis, complement factor C3a and C5a which cause atherosclerosis and cardiovascular disease occur by activation between blood and dialyzer. In this study, we mostly aimed to identify specific molecules which mainly trigger the production of C3a and C5a. Proteins absorbed by dialyzer after hemodialysis (n=6) were analyzed by mass spectrometry. Various complement factors including complement factor H, is a member of the regulators of complement activation family, were detected. Our results show that complement regulatory factors may contribute to synthesize the C3a and C5a during hemodialysis.
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| Free Research Field |
腎臓内科学
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