2015 Fiscal Year Final Research Report
Neuroregeneration by concerted regulation of cellular microenvironments
| Project/Area Number |
26750156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ナノゲル / 細胞微小環境 / 神経再生 / グリコサミノグリカン / 組織工学 / エキソソーム |
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| Outline of Final Research Achievements |
The purpose of this study is to develop the nano-matrix that mimicked cellular microenvironments for regeneration of injured neural tissues. We established the synthetic method of methacryloyl group- and cholesteryl group- bearing chondroitin sulfate (CH-GAG-MA), and successfully developed novel nanogels. We also developed the nano-matrix complexed with proteins and exosomes using CH-GAG-MA nanogels as building blocks.
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| Free Research Field |
再生医工学
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