Precise preparation of membrane-penetrating peptide nano-needle based on the control of supramolecular polymerization

2015 Fiscal Year Final Research Report

• Project/Area Number: 26750157
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: Waku Tomonori 京都工芸繊維大学, その他部局等, 助教 (30548699)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ペプチド / 自己組織化 / 超分子 / ドラッグデリバリーシステム / ナノ材料

Outline of Final Research Achievements

In previous work, we have developed beta-sheet peptide nanofibers (peptide nano-needle) loading peptide antigen for vaccine delivery system. Beta-sheet peptide nanofibers are supramolecular polymers, which are formed by self-assembly of beta-sheet peptides. If the technique to control the length of nanofibers would be established, the utility of nanofibers as delivery carrier is expected to be broaden. In this study, we addressed the development of the precise preparation method of mono-disperse peptide nanofibers based on the control of the supramolecular polymerization.

Free Research Field

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