Creation of Thermally-Dissolvable Hydrogels under Cell Culture Conditions

2015 Fiscal Year Final Research Report

• Project/Area Number: 26750158
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Shinshu University
• Principal Investigator: YOSHIDA Hiroaki 信州大学, 学術研究院繊維学系, 助教 (40727913)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 感熱応答性高分子 / ゾルーゲル転移 / ハイドロゲル / 高強度ゲル

Outline of Final Research Achievements

In this research, we synthesized chitosan derivatives in order to develop thermally-removal hydrogel scaffolds under cell culture conditions. The polymer solution in water was quickly gelled at body temperature, and the formed hydrogels was very touch, seemed like plastics rather than hydrogels. However, the hydrogels could easily return to the solution by cooling at 4oC. These results clearly show the creation of the new material “polymeric solid materials which can dissolve by lowering temperature”.

Free Research Field

高分子材料、バイオマテリアル