Multi-functional Hollow Mesoporous Silica Adjuvant for Cancer Immunotherapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 26750162
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Wang Xiupeng 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 主任研究員 (70598789)
• Co-Investigator(Renkei-kenkyūsha): Atsuo Ito 国立研究開発法人 産業技術総合研究所, 研究グループ長 (30356480)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: アジュバント / 癌免疫

Outline of Final Research Achievements

I developed a hollow mesoporous silica (HMS) nanosphere adjuvant in this study. The plain HMS nanosphere, without any immunomodulatory molecules, markedly improved anti-tumor immunity, significantly improved both Th1 and Th2 immunity, and significantly improved effector memory CD4+ and CD8+ T cell population in bone marrow in vivo. Moreover, we loaded fluorescence substance with the HMS nanospheres. These HMS nanospheres were visible under fluorescence microscope, IVIS imaging system and ultrasonic.
The HMS nanospheres showed smooth surface, uniform diameter about 200 nm, and shell thickness about 30-40 nm. The shell of the HMS nanospheres showed mesopores about 3-6 nm. The porous structure in this material is crucial for antigen adsorption and delivery, antigen cellular uptake, antigen cross-presentation, immune-related cytokines secretion, and anti-cancer immunity stimulation. The developed HMS nanospheres may be used as human cancer immunoadjuvant.

Free Research Field

総合領域