The investigation of immobilizaion-induced arthrogenic contracture and effects of vibration

2016 Fiscal Year Final Research Report

• Project/Area Number: 26750189
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagasaki University
• Principal Investigator: SASABE Ryo 長崎大学, 病院(医学系), 技術職員 (50710985)
• Co-Investigator(Renkei-kenkyūsha): OKITA Minoru 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50244091) ; NAKANO Jiro 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (20380834) ; SAKAMOTO Junya 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (20584080) ; HONDA Yuichiro 長崎大学, 病院(医学系), 技術職員 (40736344)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 不動 / 線維化 / 関節包 / 筋線維芽細胞 / コラーゲン / 振動刺激

Outline of Final Research Achievements

The purpose of this study was to examine the time-dependent changes in the development of joint capsule fibrosis and in the number of myofibroblasts in the joint capsule after immobilization and effects of vibration on jonit contracture, using a rat knee contracture model.
This study revealed that joint capsule fibrosis with overexpression of type I collagen occurs and progresses within 1 week after immobilization, and an increase in myofibroblasts is related to the mechanism of joint capsule fibrosis. However, it was indicated that the immobilization-induced joint contracture might not be inhibited by vibration stimulator.

Free Research Field

リハビリテーション科学