2015 Fiscal Year Final Research Report
Effects of different mechanical stress on discipline and metabolic of articular chondrocytes in rat
| Project/Area Number |
26750204
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Niigata University of Health and Welfare |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | メカニカルストレス / 不動 / 関節軟骨 |
|---|
| Outline of Final Research Achievements |
Degeneration of Articular cartilage induced such as osteoarthritis and immobilization. Typically, chondrocytes forms a discipline array as a column shape from joint surface. However, non-physiological mechanical stress (overloading or stress deprivation) is observed not only joint degeneration, but also loss of the number of chondrocyte. In the present study, we conducted a quantitative analysis of the chondrocyte array in Osteoarthritis (OA) model rat and immobilization model rat. As a result, the loss of chondrocyte array was confirmed in part of OA. Hence, it was inferred that chondrocyte discipline is also important factor to maintain homeostasis of articular cartilage.
|
| Free Research Field |
理学療法学
|
