Effects of hyperthermic therapy intervention for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients undergoing adjuvant chemotherapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26750225
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Cancer Center Japan (2016); Sapporo Medical University (2014-2015)
• Principal Investigator: Hikaru Ihira 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 特任研究員 (60516590)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: がんリハビリテーション / 外来化学療法 / 理学療法

Outline of Final Research Achievements

The oxaliplatin-induced peripheral neuropathy (OIPN) is manifested with the neuromyotonia-like acute transient syndrome, these symptoms have influence on the activities daily living or the quality of life in patients received outpatient chemotherapy. The purpose of this study was to examine the effect of hyperthermic therapy for OIPN in outpatient chemotherapy. Thirty four patients (22 men, 12 women, age; 63.5±11.7 years) were assessed peripheral neuropathy of hands at baseline and carried out hyperthermic therapy. Hyperthermic therapy included the wearing of thermal glove and avoidance of cold exposure in daily living. As a result from this study, although hand grip were likely to protect the functional decline, no statistically significant effect was observed in assessment items.

Free Research Field

がん疫学