Study of biomolecular repair mechanism based on reduction reaction

2015 Fiscal Year Final Research Report

• Project/Area Number: 26750368
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomolecular chemistry
• Research Institution: Kanazawa University
• Principal Investigator: Saito Yohei 金沢大学, 脳・肝インターフェースメディシン研究センター, 助教 (90723825)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 酸化ストレス / 生体防御

Outline of Final Research Achievements

It is thought that human has a mechanism protecting biomolecules from oxidative stress because reactive oxygen species (ROS) generally injure biomolecules. 8-Nitro-cGMP formed from reactive nitrogen species (RNS) and guanine nucleotide is an important mediator of autophagy and plays an important role in protein regulation. However, its removal mechanism from cells remains to be elucidated. In this study, we focused on what molecules are related to this mechanism and revealed the involvement of metal species.

Free Research Field

ケミカルバイオロジー