Clinical and demographical factors of cognitive behavioral therapy-refractory depression

2016 Fiscal Year Final Research Report

• Project/Area Number: 26780396
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical psychology
• Research Institution: Keio University
• Principal Investigator: Nakagawa Atsuo 慶應義塾大学, 医学部(信濃町), 特任講師 (30338149)
• Research Collaborator: Ono Yutaka 大野研究所 ; Abe Takayuki 慶應義塾大学, 医学部
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 認知行動療法 / うつ病

Outline of Final Research Achievements

Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. It is estimated that only a third of patients fully respond to the initial course of antidepressants and only a quarter to the second course. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. A preliminary 6-month prospective study was conducted with a sample of 51 adult patients with a diagnosis of major depressive disorder (MDD) without remarkable psychomotor disturbance using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. We found that greater personal reserve predict poorer treatment outcome.

Free Research Field

臨床精神医学