2017 Fiscal Year Final Research Report
Mechanism of oscillation in the hippocampal microcircuit
| Project/Area Number |
26780411
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Experimental psychology
|
|---|
| Research Institution | Jikei University School of Medicine (2015-2017)
Hokkaido University (2014) |
|---|
Principal Investigator |
Suzuki Etsuko 東京慈恵会医科大学, 医学部, 助教 (60424313)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 海馬 / オシレーション |
|---|
| Outline of Final Research Achievements |
The induction mechanism of theta oscillation and gamma oscillation in the hippocampus was examined. Acute hippocampal slices were obtained from mice or rats, and the acetylcholine receptor agonist carbachol was perfused to induce theta oscillation. Electrophysiological recordings were carried out in hippocampal CA3 pyramidal neurons. Stable theta oscillation was induced by carbachol at a perfusion temperature of 33-35℃. In some cases, transient gamma oscillation was also induced during a theta oscillation cycle. Carbachol-induced gamma oscillation was suppressed by a kainite-type glutamate receptor blocker.
|
| Free Research Field |
生理心理学
|
