Coupling between order formation and motion of charged lipid membranes under nonequilibrium state

2016 Fiscal Year Final Research Report

• Project/Area Number: 26800222
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Japan Advanced Institute of Science and Technology
• Principal Investigator: Shimokawa Naofumi 北陸先端科学技術大学院大学, 先端科学技術研究科, 助教 (20700181)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 相分離 / 膜変形 / 静電相互作用 / リポソーム / 脂質膜

Outline of Final Research Achievements

We investigated the phase separation and the spontaneous membrane deformation in charged lipid membranes consisting of negatively charged lipids and neutral lipids by experimental, theoretical, and numerical simulation methods. Moreover, we analyzed the fusion and motion of W/O emulsions under DC electric field. The formation of phase-separated structures and membrane morphological changes can be induced by controlling the electrostatic interaction between charged lipids. From these findings, we revealed the order formation under the electrostatic interactions. These obtained results are expected to lead to understandings of various biocellular functions and foundations of industrial applications.

Free Research Field

ソフトマター物理