The pattern formations in hepatic lobule considering the effects of the cell polarity of hepatocytes in hepatic disease rat

2016 Fiscal Year Final Research Report

• Project/Area Number: 26800225
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Shoji Hiroto 京都府立医科大学, 医学(系)研究科(研究院), 講師 (00378936)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 形態形成

Outline of Final Research Achievements

Microstructures in the liver are primarily composed of hepatocyte, hepatic blood, and biliary vessels. Because each hepatocyte comes in contact with hepatic blood, and biliary vessels, these vessels and the hepatocyte cord form 3D periodic network patterns. We have elucidated the morphogenesis of 3D microstructures in liver using imaging data of diseased rat liver. Based on the confocal image of hepatocyte and blood vessels in diseased liver and the quantitative data of blood flow, we have performed an allometric analysis of 3D morphological changes in liver. We also discuss the physical effect to morphogenesis by using the fractal index of patterns of the blood vessel.

Free Research Field

数理生物学