Robust mechanism of cellular information processing explored from fluctuation of cell movement

2017 Fiscal Year Final Research Report

• Project/Area Number: 26800226
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Nara Medical University
• Principal Investigator: TAKAGI Hiroaki 奈良県立医科大学, 医学部, 講師 (10444514)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 細胞運動 / 自発性 / 細胞走性 / 時系列解析 / 数理モデル / 細胞性粘菌

Outline of Final Research Achievements

We carried out basic researches to capture the mechanism of information processing of cells from the viewpoint of spontaneous movement (random movement without external stimulus) and fluctuation of cells. We performed comprehensive statistical analysis of spontaneous movement not only in wild-type and mutants of Dictyostelium cells, but also in wild-type mouse T cells and nerve cells. We quantitatively confirmed the common aspects in the statistical features and the applicable mathematical model. Based on the general results obtained there, we proposed a new scheme that spontaneous movement and fluctuation of cells play an active role in producing cellular flexible directional movement (the output of cellular information processing) against external stimulus and its change.

Free Research Field

生物物理学，定量生物学