Asymmetric Autocatalysis Induced by Crystal or Surface Chirality of Achiral Compounds

2016 Fiscal Year Final Research Report

• Project/Area Number: 26810026
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Organic chemistry
• Research Institution: Tokyo University of Science
• Principal Investigator: Matsumoto Arimasa 東京理科大学, 理学部第一部応用化学科, 講師 (20633407)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 有機化学 / 結晶構造 / キラリティー / 不斉合成 / 結晶表面 / 不斉増幅

Outline of Final Research Achievements

Some achiral compounds have a chirality in the crystal structure or crystal surface. The main purpose of this study is achieving the asymmetric induction in molecular chirality by using crystal chirality or surface chirality without any chiral compounds.
In the course of this study, asymmetric induction with chiral crystal of achiral ethylendiamine sulfate, phenol derivatives, and nickel sulfate hexahydrate were achieved by using asymmetric amplification effect of asymmetric autocatalytic reaction.
Furthermore, asymmetric autocatalysis induced by surface chirality also achieved by using the 2-dimentional surface chirality of achiral gypsum crystal. This is the first example of asymmetric induction of reaction selectivity by using the surface chirality of crystal.

Free Research Field

有機化学