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2015 Fiscal Year Final Research Report

Universal Methodology for Drug Development Based on Stimuli-responsive Molecular Glues

Research Project

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Project/Area Number 26810046
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional solid state chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

Okuro Kou  東京大学, 工学(系)研究科(研究院), 助教 (60614360)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywords分子糊 / 刺激応答性 / 光重合 / siRNA / ATP / 酵素阻害剤
Outline of Final Research Achievements

By conjugation of a molecular glue with an enzyme inhibitor, >30-times binding affinity and >10-times inhibitory effect were achieved. The results support the concept that drug efficacy can be enhanced by simply introducing an “adhesive" moiety. In this research project, we had mainly focused on development of stimuli-responsive molecular glues, though different from the original plan, and succeeded in synthesis of “photo-polymerizable”, “redox-responsive”, and “ATP-binding” molecular glues. Each of the molecular glues demonstrates a remarkable properties to manipulate biological functions. The development of new stimuli-responsive molecular glues will definitely promote the project toward treatment of unmet-needs diseases.

Free Research Field

ケミカルバイオロジー

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Published: 2017-05-10  

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