Development of a Hierarchical Chiral Information Transfer System and Its Application

2015 Fiscal Year Final Research Report

• Project/Area Number: 26810047
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional solid state chemistry
• Research Institution: Nagoya University
• Principal Investigator: Ousaka Naoki 名古屋大学, 工学(系)研究科(研究院), 講師 (80726331)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: らせん構造 / ペプチド / キラリティ

Outline of Final Research Achievements

Planar chiral salen-based metallomacrocycles bearing dynamic helical peptide chains were efficiently synthesized through self-assembly of their corresponding ligands, diamines, and metal ions. The planar chirality of the resulting macrocycles can be remotely controlled through an induction of a preferred-handed 310-helical structure in the dynamic oligopeptide chain by a chiral amino acid residue far from the macrocycle framework. The remote-controlled planar chirality was almost completely locked as a result of a solvent-induced 310-to-α-helix transition of the pendant peptide chains. In addition, remote stereocontrol of an axially chiral bipyridine bearing dynamic helical peptide chains was also achieved.

Free Research Field

超分子化学