2016 Fiscal Year Final Research Report
Modular Synthesis of Arylalkanes Using Organosulfur Compounds
| Project/Area Number |
26810056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
Nambo Masakazu 名古屋大学, トランスフォーマティブ生命分子研究所, 特任助教 (10705528)
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| Research Collaborator |
CRUDDEN Cathleen M. クイーンズ大学, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アリールアルカン / 炭素-スルホニル結合活性化 / 有機硫黄化合物 / パラジウム触媒 / 逐次的自在合成 / C-H官能基化 / 有機ホウ素化合物 |
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| Outline of Final Research Achievements |
We have developed methyl sulfone derivatives as new reacting templates in Pd-catalyzed sequential arylations directed toward the modular synthesis of multiply-arylated methanes. This method enabled the rapid synthesis of thyroid hormone receptor b-selective analog (GC-24) and the development of new inhibitor for plant cell division.
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| Free Research Field |
有機合成化学
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