2017 Fiscal Year Final Research Report
Cross-Coupling Reactions Based on Catalytically Generated Organometallics via Addition of Metal Species
| Project/Area Number |
26810058
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | クロスカップリング反応 / 金属協働触媒 |
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| Outline of Final Research Achievements |
Cross-coupling reaction is a versatile method for carbon-carbon bond constructions. Cross-coupling reactions generally require pre-synthesis and purification of organometallics prior to the desired carbon-carbon bond formation. In contrast to the conventional cross-coupling reactions, cross-coupling reactions based on catalytically generated organometallics are more atom- and step-economical. Here, we have developed alkylation and alkenylation of organic electrophiles based on catalytically generated organocoppers via hydrocupration, borylcupration, and carbocupration of alkenes and alkynes. These reactions can afford highly functionalized alkanes and alkenes from readily available starting materials in highly step- and atom-economical manners.
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| Free Research Field |
有機金属化学
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