2016 Fiscal Year Final Research Report
Development Study of New Environmentally Friendly Antifouling Agents by Mimicking Marine Natural Products
| Project/Area Number |
26810061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 天然物合成 / 着性阻害活性 / 不斉合成 / ヨウ化サマリウム |
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| Outline of Final Research Achievements |
Synthetic study toward the total synthesis of dolastane-type diterpene, a marine natural product which exhibit potent antifouling activity against the mussel, was carried out to develop new antifouling agent for ship. Toward the total synthesis of dolastane-type diterpene, the construction of the bicyclo[5. 4. 0]undecane skeleton was achieved by utilizing the reductive Knoevenagel condensation with Hantzsch ester, the Corey-Bakshi-Shibata asymmetric reduction, and the SmI2-initiated radical cyclization as key steps. And synthesis of cis-fused bicyclic skeleton of toxicodenane A, a sesquiterpene derived from the family anacardiaceae, was also accomplished according to the above synthetic method.
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| Free Research Field |
有機合成化学
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