2016 Fiscal Year Final Research Report
Green synthesis of oligopeptides in the inverse direction by a novel, thiol-relay method
| Project/Area Number |
26810062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ペプチド合成 / グリーン合成 / アミド結合形成 |
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| Outline of Final Research Achievements |
The most reliable and generally used method for preparation of oligopeptides is currently solid-supported synthesis, which requires excess monomers, excess dehydrating agents and protective group manipulations. We consider this classical method to be updated to circumvent its low atom economy, and design a novel method named ‘thiol-relay,’ which discharges only carbon dioxide along with construction of a peptide bond. First, we improved an access to the thiocarboxylic acid, a key function in thiol-relay method, by introducing a novel, easy-to-prepare, and easy-to-handle precursor. The basic concept of thiol-relay peptide synthesis was proven, and we also found some problems toward more practical use of this method.
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| Free Research Field |
有機合成化学
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