2015 Fiscal Year Annual Research Report
Enhanced Cell Evaluation by Phase Decomposition
| Project/Area Number |
26820086
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| Research Institution | Osaka University |
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Principal Investigator |
蔡 佳宏 大阪大学, 工学(系)研究科(研究院), 講師(常勤) (20647490)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | cell deformability / red blood cell / microfluidics / pressure sensor |
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| Outline of Annual Research Achievements |
A microfluidic method to evaluate cell deformability with phase decomposition has been developed and tested in FY2014, and has been applied in patients' cells research in FY2015. The relation between the deformability and diseases has be investigated through the collaboration with medical doctors. The preliminary results show that patients with cardiovascular diseases tend to have more distributed deformability of their red blood cells (RBC) because of greater variations of RBC size compared with healthy subjects. The proposed phase decomposition method successfully separates RBC deformability into stiffness-based and viscosity-based deformabilities.
An on-chip pressure sensor is also developed for assisting deformability evaluation in FY2015. The sensor mechanism and performance is published in Biomicrofluidics, a journal of American institute of physics.
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