Development of high definition multi-wavelength holographic tomography for biological measurement

2015 Fiscal Year Final Research Report

• Project/Area Number: 26820155
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Measurement engineering
• Research Institution: Niigata University
• Principal Investigator: Samuel Choi 新潟大学, 自然科学系, 助教 (60568418)
• Co-Investigator(Renkei-kenkyūsha): HIBINO Hiroshi 新潟大学, 医歯学系, 教授 (70314317) ; NIN Fumiaki 新潟大学, 医歯学系, 准教授 (80644905)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 光コヒーレンストモグラフィ / 光生体計測 / 光エレクトロニクス

Outline of Final Research Achievements

In this study, aiming for a high-precision tomographic imaging with nm precision in biological tissues, multi-wavelength holographic high-definition optical coherence tomography technique was developed through medical-engineering cooperation. The "en-face multi-frequency swept OCT" was produced as a practical method of evolutionary principle of multi-wavelength holographic interferometry, which allowed three-dimensional tomographic measurement of biological samples with a resolution of 2.5 micrometer. In addition, we have developed the "wide-field heterodyne interference vibrometry" as a technology that can obtain spatial vibrational distributions within the field of view of the microscope image. The combination of these two basic technologies were able to measure tomographic images and minute vibrations of interior surfaces in a thick bio-tissue at 10 kHz with nm accuracy.

Free Research Field

光エレクトロニクス