Development of bio-patch materials encapsulating growth factors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26820304
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Composite materials/Surface and interface engineering
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: Obata Akiko 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (40402656)
• Research Collaborator: MIZUNO Toshihisa ; IWANAGA Norihiko ; IGUCHI Makito ; OZEKI Yuto
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: バイオマテリアル / 有機無機ハイブリッド / 不織布 / 生分解性 / タンパク質担持

Outline of Final Research Achievements

Organic/inorganic hybrid fibre mats which have biodegradability and cell compatibility were developed for the use in tissue regeneration. The fibre mats were synthesized using water as a solvent, which can contribute to their eco-friendly synthesis, excellent safety for application to biomaterials, and original ability of encapsulating proteins and drugs without their denaturation. For example, the enzymic proteins which are encapsulated in the fibres could exhibit their enzymic activity and are protected from denaturation or degradation by protease in surroundings since they exist inside of the fibres and hybrid structures of the fibres keep such protease away from them. This is because molecule penetration into the hybrid structures possesses molecular-size dependence; no big molecules, such as proteases, can migrate into inside of the fibres.

Free Research Field

生体材料