Tissue adhesive using quinone-crosskinked gelatin

2016 Fiscal Year Final Research Report

• Project/Area Number: 26820324
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Structural/Functional materials
• Research Institution: Osaka Municipal Technical Research Institute
• Principal Investigator: YAMAUCHI Asao 地方独立行政法人大阪市立工業研究所, 生物・生活材料研究部, 研究主任 (80416304)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 接着タンパク質 / ポリフェノール / 酸化 / キノン / ゼラチン / 耐水

Outline of Final Research Achievements

The gelatin adhesive was improved by conjugating tyrosinase-catalyzed oxidation of phenolic compounds. The gelatin protein molecules were covalently crosslinked by the phenol oxidation products, the quinones, to form an insoluble polymeric substance. Indeed, the crosslinked adhesive using a natural polyphenol, caffeic acid, remarkably enhanced moisture resistance and waterproof property. The present quinone crosslinking reaction hence may be potentially useful for fabricating new formaldehyde-free gelatin glue for tissue.

Free Research Field

タンパク質工学