Regulation of local sleep by cortical adenosine

2016 Fiscal Year Final Research Report

• Project/Area Number: 26830002
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: University of Tsukuba
• Principal Investigator: OHYAMA Kaoru 筑波大学, 国際統合睡眠医科学研究機構, 研究員 (30713044)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 睡眠 / マウス / 電気生理 / 徐波

Outline of Final Research Achievements

Slow wave sleep is an indicator of sleep need, which mechanism has not yet been uncovered. We investigated single-unit activity of cortex from freely behaving mice to understand how neuronal activity and network of neurons change across waking and slow wave sleep. Activity of neurons showed rhythmic and synchronized activity during slow wave sleep and more bursting for excitatory neurons. In spite of the synchronisity, network of neurons was weaker in slow wave sleep than in waking. Combination of calsium imaging and modeling of unit activity showed that burst of neurons increase influx of calcium into cells. These results suggest that unit activity in cortex could be a good evaluation for calcium activity in cortex.

Free Research Field

神経生理学　睡眠