2017 Fiscal Year Final Research Report
Analysis of mechanisms regulating memory consolidation and forgetting
Project/Area Number |
26830003
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Chiba University |
Principal Investigator |
Tonoki Ayako 千葉大学, 大学院薬学研究院, 講師 (90645425)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Keywords | 老化 / 記憶 / 忘却 / ショウジョウバエ / ドーパミン / ニューロペプチド |
Outline of Final Research Achievements |
The formation of memory declines with advancing age. However, susceptibility to memory impairments depends on the robustness of memory. In this study, we aimed to reveal how age-dependent changes in neural circuits affect memory formation by using Drosophila genetics and behavior analysis. We succeeded to show that memory declines are caused by age-dependent changes in neural circuits including a subset of dopaminergic neurons and neuropeptides expressing neurons.
|
Free Research Field |
神経科学
|