Analysis of mechanisms regulating memory consolidation and forgetting

2017 Fiscal Year Final Research Report

• Project/Area Number: 26830003
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Chiba University
• Principal Investigator: Tonoki Ayako 千葉大学, 大学院薬学研究院, 講師 (90645425)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 老化 / 記憶 / 忘却 / ショウジョウバエ / ドーパミン / ニューロペプチド

Outline of Final Research Achievements

The formation of memory declines with advancing age. However, susceptibility to memory impairments depends on the robustness of memory. In this study, we aimed to reveal how age-dependent changes in neural circuits affect memory formation by using Drosophila genetics and behavior analysis. We succeeded to show that memory declines are caused by age-dependent changes in neural circuits including a subset of dopaminergic neurons and neuropeptides expressing neurons.

Free Research Field

神経科学