Gene expression analysis along the tonotopic axis of the chicken

2016 Fiscal Year Final Research Report

• Project/Area Number: 26830011
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Kyoto University
• Principal Investigator: Matsui Ryosuke 京都大学, 医学研究科, 助教 (80633940)
• Research Collaborator: WATANABE DAI 京都大学, 医学研究科
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 音源定位 / トノトピー / 遺伝子発現

Outline of Final Research Achievements

Neurons in the auditory pathway are topographically arranged by their response to different auditory frequencies. Although tonotopic organization is a fundamental structure for frequency processing, the molecular mechanisms of the tonotopic map formation are largely unknown. In this study, we analyzed the gene expression profiles of two brainstem regions, nucleus laminaris and nucleus magnocellularis, to identify genes that are differentially expressed along the tonotopic axis. As a result, more than hundred molecules expressed in frequency-dependent manner and the most enriched pathway was axon guidance. These data should be useful for understanding the molecular mechanisms of the tonotopic map formation.

Free Research Field

神経科学