Reward dependent synaptic plasticity during single neuron operant conditioning

2015 Fiscal Year Final Research Report

• Project/Area Number: 26830021
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: National Institute for Basic Biology
• Principal Investigator: Hira Riichiro 基礎生物学研究所, 光脳回路研究部門, 助教 (80712299)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ブレインマシーンインターフェース / ２光子イメージング / 光遺伝学

Outline of Final Research Achievements

In this study, we developed several new methods including a real time analysis system of images obtained by two photon calcium imaging of cortical neurons and an experimental system that allowed us to simultaneously conduct two photon imaging and the optogenetic stimulation. We found that the reward timing dependent bidirectional modulation (RTBM) of cortical neurons during the learning of the single neuron operant conditioning. The RTBM might be one of the key mechanism that enables animal to learn to use brain machine interface.

Free Research Field

神経科学