Genetic analysis of embryonal brain tumors with multilayered rosettes

2015 Fiscal Year Final Research Report

• Project/Area Number: 26830034
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Gunma University
• Principal Investigator: Nobusawa Sumihito 群馬大学, 医学(系)研究科(研究院), 助教 (80635318)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 胎児性脳腫瘍 / 多層性ロゼット

Outline of Final Research Achievements

Ependymoblastomas, embrynal tumors with abundant neuropil and true rosettes (ETANTR) and medulloepitheliomas are subtypes of central nervous system primitive neuroectodermal tumors. Recent data suggest that these tumors constitute a single entity, embryonal tumors with multilayered rosettes (ETMR), for which 19q13.42 amplification represents a specific molecular hallmark, and that LIN28A is a specific immunohistochemical marker for ETMR. We analyzed LIN28A immunohistochemical expression in ETMR and their histological mimics with multilayered rosettes, atypical teratoid/rhabdoid tumors (AT/RT), immature teratomas and anaplastic ependymomas, and found that LIN28A can be used for differentiation between ETMR and anaplastic ependymomas but is not useful for differentiation of ETMR from AT/RT and immature teratomas.

Free Research Field

病理学