Evaluation of new generation translocator protein ligand efficacy in a mouse model of Alzheimer`s disease.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26830038
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: Barron Anna 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (40725694)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: Alzheimer`s / Dementia / hormone replacement

Outline of Final Research Achievements

Our previous work has demonstrated that ligands of the translocator protein (TSPO) are protective in a mouse model of Alzheimer`s disease. The purpose of this study was to characterize the potential suitability of three new generation TSPO ligands. We tested the ability of the new generation TSPO ligands to penetrate the brain of living mice, as well as their ability to bind TSPO in human brain sections. Next we assessed their effect on memory, anxiety and depression-related behaviors in mice. All three TSPO ligands improved memory function and one also reduced depression-related behavior. TSPO ligands are thought to improve memory by increasing brain hormone production. Confirming this mechanism of action, memory improvements in TSPO-ligand treated mice were blocked by inhibition of hormone production. Our findings indicate these new TSPO ligands may be promising therapeutic candidates for the treatment of Alzheimer`s disease.

Free Research Field

Neuroscience