2015 Fiscal Year Final Research Report
Analysis of plasma membrane monoamine transporter in brain
| Project/Area Number |
26830041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
Yoshikawa Takeo 東北大学, 医学(系)研究科(研究院), 准教授 (70506633)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | モノアミン / トランスポーター |
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| Outline of Final Research Achievements |
Plasma membrane monoamine transporter (PMAT) is one of the monoamine transporters in brain. However, the role of PMAT in the regulation of monoamine concentration remains to be elucidated. In the present study, we generated PMAT-deficient mice, but analysis of PMAT-deficient mice is now on going. We also try to develop specific inhibitors against PMAT. We performed high-throughput screening to get PMAT specific inhibitors and got some candidate compounds until now.
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| Free Research Field |
薬理学
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