The mechanism for regulating activated glial cells by immune cells in amyotrophic lateral screlosis mice.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26830046
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya University
• Principal Investigator: KOMINE Okiru 名古屋大学, 環境医学研究所, 助教 (00456211)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 筋萎縮性側索硬化症 / 自然免疫 / グリア細胞 / 免疫細胞

Outline of Final Research Achievements

From our analyses of innate immune TRIF-pathway deficiency and increase or decrease in number of specific infiltrating immune cells in ALS model mice, it was suggested that the induction of cell-death in dysmorphic activated astrocytes was regulated by not immune cell mediated Fas-pathway but cell-autonomous TRIF-pathway in ALS model mice. Meanwhile, from comparative analyses between two strains of ALS model mice that have distinct genetic backgrounds in peripheral immune responses, we found that the peripheral immune response might affect to a disease course and a microglia number in ALS model mice. These results suggest that peripheral immune system contributes to a disease course of ALS.

Free Research Field

基礎医学　薬理学一般