2015 Fiscal Year Final Research Report
Inhibition of the maintenance of stemness of glioma initiating cells for clinical applications
| Project/Area Number |
26830067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
|
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| Research Institution | Kinki University (2015)
The University of Tokyo (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | がん幹細胞 / 脳腫瘍 / BMP / 融合遺伝子 |
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| Outline of Final Research Achievements |
We attempted to enhance Bone Morphogenetic Protein (BMP) signal in glioma initiating-cells (GICs) by using of siRNA for Smad6 which is the intracellular inhibitor of BMP signal, we observed that BMP4+siSmad6 dramatically inhibited the maintenance of stemness of GICs. Furthermore, we identified several target genes of BMP4+siSmad6 that had the inhibitory effects of the maintenance of stemness of GICs. Additionally, we discovered several novel fusion genes in GICs by using RNA-Seq of this study, and we found that one of fusion genes identified had the transforming potential and high tumor-forming capacity.
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| Free Research Field |
腫瘍生物学、分子生物学
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